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. 2012 Oct 30:10:88.
doi: 10.1186/1477-7827-10-88.

Effects on steroid hormones secretion resulting from the acute stimulation of sectioning the superior ovarian nerve to pre-pubertal rats

Leticia Morales-Ledesma  1 , Elizabeth Vieyra, Deyra A Ramírez, Angélica Trujillo, Roberto Chavira, Mario Cárdenas, Roberto Domínguez
Affiliations

Effects on steroid hormones secretion resulting from the acute stimulation of sectioning the superior ovarian nerve to pre-pubertal rats

Leticia Morales-Ledesma et al. Reprod Biol Endocrinol. .

Abstract

In the adult rat, neural signals arriving to the ovary via the superior ovarian nerve (SON) modulate progesterone (P4), testosterone (T) and estradiol (E2) secretion. The aims of the present study were to analyze if the SON in the pre-pubertal rat also modulates ovarian hormone secretion and the release of follicle stimulating hormone (FSH) and luteinizing (LH) hormone. P4, T, E2, FSH and LH serum levels were measured 30 or 60 minutes after sectioning the SON of pre-pubertal female rats. Our results indicate that the effects on hormone levels resulting from unilaterally or bilaterally sectioning the SON depends on the analyzed hormone, and the time lapse between surgery and autopsy, and that the treatment yielded asymmetric results. The results also suggest that in the pre-pubertal rat the neural signals arriving to the ovaries via the SON regulate the enzymes participating in P4, T and E2 synthesis in a non-parallel way, indicating that the mechanisms regulating the synthesis of each hormone are not regulated by the same signals. Also, that the changes in the steroids hormones are not explained exclusively by the modifications in gonadotropins secretion. The observed differences in hormone levels between rats sacrificed 30 and 60 min after surgery reflect the onset of the compensatory systems regulating hormones secretion.

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Figures

Figure 1
Figure 1
Progesterone (P4) serum levels in rats with unilateral or bilateral sectioning of the superior ovarian nerve (SON). Mean ± S.E.M. of P4 levels in serum. Left (L-LAP), right (R-LAP), bilateral (B-LAP) laparotomy, with sectioning of the left superior ovarian nerve (L-SON), right (R-SON) or bilateral (B-SON) performed to 32 days of age. Animals were sacrificed 30 or 60 minutes after surgery. p<0.05 vs. control (MANOVA followed by a Tukey′s test).*p<0.05 vs. its respective LAP group (Student′s t-test). ♦ indicating vs. control group.
Figure 2
Figure 2
Testosterone (T) serum levels in rats with unilateral or bilateral sectioning of the superior ovarian nerve (SON). Mean ± S.E.M. of T levels in serum. Left (L-LAP), right (R-LAP), bilateral (B-LAP) laparotomy, with sectioning of the left superior ovarian nerve (L-SON), right (R-SON) or bilateral (B-SON) performed on 32 days of age. Animals were sacrificed 30 or 60 minutes after surgery. p< 0.05 vs. control (MANOVA followed by a Tukey′s test).*p<0.05 vs. its respective LAP group (Student′s t-test). ♦ indicating vs. control group.
Figure 3
Figure 3
Estradiol (E2) serum levels in rats with unilateral or bilateral sectioning of the superior ovarian nerve (SON). Mean ± S.E.M. of E2 levels in serum. Left (L-LAP), right (R-LAP), bilateral (B-LAP) laparotomy, with sectioning of the left superior ovarian nerve (L-SON), right (R-SON) or bilateral (B-SON) sectioning performed on 32 days of age. Animals were sacrificed 30 or 60 minutes after surgery. p<0.05 vs. control (MANOVA followed by a Tukey′s test).*p<0.05 vs. its respective LAP group (Student′s t-test). ♦ indicating vs. control group.
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