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. 2011 Nov;73(6):674-8.
doi: 10.4103/0250-474X.100246.

Synthesis and Evaluation of N-substituted Imidazole Derivatives for Antimicrobial Activity

Namita Gupta  1 , D P Pathak
Affiliations

Synthesis and Evaluation of N-substituted Imidazole Derivatives for Antimicrobial Activity

Namita Gupta et al. Indian J Pharm Sci. 2011 Nov.

Abstract

A series of N-substituted imidazole derivatives was synthesized. Imidazole nucleus was reacted with ethylchloroacetate to form imidazole ester. Reaction of the imidazole ester (I) with different amines yields the desired products (1a- 1e). The compounds were characterized by FT-IR, (1)H-NMR and mass spectra. The synthesized compounds were evaluated for the antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger by determination of MIC (minimum inhibitory concentration) using tube dilution method. Compound (1b) was found to be the most active antimicrobial compound amongst others in the series.

Keywords: 1H-NMR; FT-IR; imidazole; minimum inhibitory concentration; tube dilution method.

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Figures

Fig. 1
Fig. 1
Synthesis of N-substituted imidazole derivatives Figure shows the reaction between imidazole and ethylchloroacetate in the presence of potassium carbonate at 60°. The resulting intermediate (I) reacts with different amines to form the products (1a-1e).
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