Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Sep-Oct;44(5):576-9.
doi: 10.4103/0253-7613.100378.

Study of antiurolithiatic activity of Asparagus racemosus on albino rats

Narumalla Jagannath  1 , Somashekara S Chikkannasetty, Damodaram Govindadas, Golla Devasankaraiah
Affiliations

Study of antiurolithiatic activity of Asparagus racemosus on albino rats

Narumalla Jagannath et al. Indian J Pharmacol. 2012 Sep-Oct.

Abstract

Aims: The aim of this study was to investigate the effect of ethanolic extract of Asparagus racemosus on urolithiasis in rats.

Materials and methods: Thirty-six male Wistar albino rats were randomly divided into six groups (n = 6). Ethylene glycol (EG) 0.75% and ammonium chloride (AC) 2% in drinking water were fed to all groups (Groups II-VI) except normal control (Group I) rats for 10 days to induce urolithiasis. Group III-VI rats were treated with ethanolic extract of Asparagus racemosus at doses 200, 400, 800, and 1600 mg/kg, respectively, for 10 days. Positive control (Group II) rats were treated with EG/AC alone. Group I rats were administered drinking water and distilled water (6 μl/g) by gavage. After 10 days, blood samples were collected and analyzed for serum concentrations of calcium, phosphorus, urea, and creatinine. The kidneys were removed and sectioned for histopathological examination. The data were presented as mean ± standard error of mean and analyzed using one-way analysis of variance and Student's "t"-test. P < 0.05 was considered statistically significant. Conventional windows software was used for statistical analysis.

Results: The rats treated with ethanolic extract of A. racemosus at doses 800 and 1600 mg/ kg significantly (P < 0.05) reduced the serum concentrations of calcium, phosphorus, urea, and creatinine. Histopathology of the kidneys in Groups V and VI revealed less tissue damage and were almost similar to Group I rats.

Conclusions: The ethanolic extract of A. racemosus has protective effect against urolithiasis.

Keywords: Ammonium chloride; Asparagus racemosus; antiurolithiatic activity; ethylene glycol.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Histology of kidney sections. There is marked dilatation of tubules and crystal deposition in Group II rats. Histology of Group V and IV rats are almost similar to Group I
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Marshall L, Stoller MD. Urinary stone disease. In: Tanagho EA, McAninch JW, editors. Smith's General Urology. 16th ed. New York: McGraw-Hill Lange Medical Books; 2004. pp. 256–91.
    1. Khan SR. Interactions between stone-forming calcific crystals and macromolecules. Urol Int. 1997;59:59–71. - PubMed
    1. Atmani F, Slimani Y, Mimouni M, Hacht B. Prophylaxis of calcium oxalate stones by Herniaria hirsute on experimentally induced nephrolithiasis in rats. BJU Int. 2003;92:137–40. - PubMed
    1. Ashok P, Koti BC, Vishwanathswamy AH. Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats. Indian J Pharmacol. 2010;42:380–3. - PMC - PubMed
    1. Suman KM, Satyaranjan M, Sabuj S, Prasannakumar P. Antiurolithiatic activity of Cratavera manga Lour.bark. Indian J Nat Prod Resour. 2011;2:28–33.