Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Sep-Oct;44(5):614-8.
doi: 10.4103/0253-7613.100389.

Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease

Jayanti P Behera  1 , Bisweswar Mohanty, Y Roja Ramani, Bandana Rath, Supriya Pradhan
Affiliations

Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease

Jayanti P Behera et al. Indian J Pharmacol. 2012 Sep-Oct.

Abstract

Objective: The present study was designed to evaluate the effect of Aegle marmelos unripe fruit extract (AMFE) on inflammatory bowel disease (IBD) in Wistar albino rats.

Materials and methods: Effect of AMFE was studied on acetic acid induced ulcerative colitis (1 ml of 4% acetic acid solution, transrectal) and indomethacin-induced enterocolitis (10 mg/kg, single dose, p.o) in Wistar albino rats. The extract was administered orally at different dose of 150, 200 and 250 mg/kg body weight. Disease pathogenesis was assessed by measuring disease activity index (DAI), macroscopic score, microscopic score, mesenteric mast cell protection, superoxide dismutase (SOD), and malonaldehyde (MDA) levels in the above two models.

Results: The results showed a dose dependent decrease in intestinal inflammation following treatment with AMFE. Significant protection in mast cell degranulation was observed in acetic acid and indomethacin-induced IBD models. Treatment with AMFE significantly decreased the MDA levels and increased SOD activity.

Conclusion: In our study, AMFE produced anti-inflammatory, antioxidant, and mast cell stabilizing effects demonstrating protective effect in inflammatory bowel disease.

Keywords: Aegle marmelos (bael); aqueous extract; inflammatory bowel disease.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Histological changes seen with aqueous extract of Aegle marmelos unripe fruit on acetic acid induced ulcerative colitis (a) normal control (b) disease control (c) prednisolone (1 mg/kg) (d) AMFE (250 mg/kg)
Figure 2
Figure 2
Histological changes seen with aqueous extract of Aegle marmelos unripe fruit on indomethacin induced enterocolitis (a) normal control (b) disease control (c) prednisolone (1 mg/kg) (d) AMFE (250 mg/kg)
See this image and copyright information in PMC

References

    1. Sellin JH, Pasricha PJ. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11th ed. NewYork: McGraw-Hill Publications; 2006. Pharmacotherapy of inflammatory bowel disease; p. 1009.
    1. Bickson SJ. Treatment of chronic disease at the turn of the century. N Engl J Med. 1998;339:401–2. - PubMed
    1. Hana Strul MD, Nadir Arber MD. Inflammatory bowel disease, ulcerative colitis, Crohn's disease, pathophysiology, new therapies. IMAJ. 2000;2:607–9. - PubMed
    1. Parkes M, Jewell D. Ulcerative Colitis and Crohn's disease: Molecular genetics and clinical implications. Expert Rev Mol Med. 2001;2001:1. 1800391-Xa.pdf. - PubMed
    1. Calkins BM, Mendeloff AI. The epidemiology of idiopathic inflammatory bowel disease. In: Kirsner JB, Shorter RG, editors. Inflammatory Bowel Disease. 4th ed. Baltimore: Williams and wilkins; 1995. pp. 31–68.