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Review
. 2012 Oct 21;18(39):5495-503.
doi: 10.3748/wjg.v18.i39.5495.

Diagnosis of Zollinger-Ellison syndrome: increasingly difficult

Tetsuhide Ito  1 , Guillaume Cadiot, Robert T Jensen
Affiliations
Review

Diagnosis of Zollinger-Ellison syndrome: increasingly difficult

Tetsuhide Ito et al. World J Gastroenterol. .

Abstract

In the present paper the increasing difficulty of diagnosis of Zollinger-Ellison syndrome (ZES) due to issues raised in two recent papers is discussed. These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors (omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole) and the unreliability of many gastrin radioimmunoassays. The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the perspective of clinical management.

Keywords: Gastrin; Gastrinoma; Hypergastrinemia; Neuroendocrine tumor; Secretin test; Serum gastrin; Zollinger-Ellison syndrome.

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