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Review
. 2012 Oct 21;18(39):5495-503.
doi: 10.3748/wjg.v18.i39.5495.

Diagnosis of Zollinger-Ellison syndrome: increasingly difficult

Tetsuhide Ito  1 , Guillaume Cadiot, Robert T Jensen
Affiliations
Review

Diagnosis of Zollinger-Ellison syndrome: increasingly difficult

Tetsuhide Ito et al. World J Gastroenterol. .

Abstract

In the present paper the increasing difficulty of diagnosis of Zollinger-Ellison syndrome (ZES) due to issues raised in two recent papers is discussed. These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors (omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole) and the unreliability of many gastrin radioimmunoassays. The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the perspective of clinical management.

Keywords: Gastrin; Gastrinoma; Hypergastrinemia; Neuroendocrine tumor; Secretin test; Serum gastrin; Zollinger-Ellison syndrome.

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References

    1. Poitras P, Gingras MH, Rehfeld JF. The Zollinger-Ellison syndrome: dangers and consequences of interrupting antisecretory treatment. Clin Gastroenterol Hepatol. 2012;10:199–202. - PubMed
    1. Rehfeld JF, Gingras MH, Bardram L, Hilsted L, Goetze JP, Poitras P. The Zollinger-Ellison syndrome and mismeasurement of gastrin. Gastroenterology. 2011;140:1444–1453. - PubMed
    1. Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V, Scarpa A, Sundin A, Perren A, Gross D, et al. Gastrinoma (duodenal and pancreatic) Neuroendocrinology. 2006;84:173–182. - PubMed
    1. Ellison EC, Johnson JA. The Zollinger-Ellison syndrome: a comprehensive review of historical, scientific, and clinical considerations. Curr Probl Surg. 2009;46:13–106. - PubMed
    1. Gibril F, Jensen RT. Zollinger-Ellison syndrome revisited: diagnosis, biologic markers, associated inherited disorders, and acid hypersecretion. Curr Gastroenterol Rep. 2004;6:454–463. - PubMed