Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012;41(4):26-34.
Epub 2012 Apr 30.

An exploratory analysis of dynamic change of metabolic syndrome in relation to the risk of developing cardiovascular disease in a chinese cohort

H Zhou  1 , Zr Guo, Xs Hu, Lg Yu, Bh Xu, M Wu, Zy Zhou, C Yang; Group PMMJS Study
Affiliations

An exploratory analysis of dynamic change of metabolic syndrome in relation to the risk of developing cardiovascular disease in a chinese cohort

H Zhou et al. Iran J Public Health. 2012.

Abstract

Background: Metabolic syndrome (MS) is the syndrome closely related to cardiovascular disease (CVD) risk factors. Few prospective studies have compared the impact of dynamic changes of MS on the development of cardiovascular diseases (CVD).

Methods: Overall, 3461 subjects were recruited from a cohort study on Prevention of Multiple Metabolic disorders and MS in Jiangsu of China (PMMJS) with a follow up of 3.8 years. The associations between the dynamic changes (Difference, the value at first follow-up subtract the value at baseline) of MS, component numbers, components and relative risk (RR) of CVD were analyzed by using Cox regression model.

Results: The total incidence standardized rate of CVD was 2.58%,and the incidence standardized rates of CVD in MS-/follow-up MS-,baseline MS-/follow-up MS+, baseline MS+/follow-up MS- and baseline MS+/follow-up groups were 2.05%,5.01%,1.65% and 4.39% separately. After adjustment confounding factors Difference in FPG, BP and TG have significantly effects on the incidence of CVD.

Conclusion: Difference of MS component numbers had the prediction ability of CVD, but MS groups based on baseline and first follow-up MS and/or non-MS had not. In Chinese, the dynamic change of MS component numbers was a useful predict factor for CVD.

Keywords: Age; Cardiovascular disease; China; Dynamic change; Metabolic syndrome.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595–1607. - PubMed
    1. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365(9468):1415–1428. - PubMed
    1. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C. American Heart Association; National Heart Lung, and Blood Institute. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109(3):433–438. - PubMed
    1. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288(21):2709–2716. - PubMed
    1. Hoshino A, Nakamura T, Enomoto S, Kawahito H, Kurata H, Nakahara Y, Ijichi T. Prevalence of coronary artery disease in Japanese patients with cerebral infarction: Impact of metabolic syndrome and intracranial large artery atherosclerosis. Circ J. 2008;72(3):404–408. - PubMed

LinkOut - more resources