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Case Reports
. 2013 Jan;57(1):674-6.
doi: 10.1128/AAC.01086-12. Epub 2012 Oct 31.

Comparative genomics of IncL/M-type plasmids: evolution by acquisition of resistance genes and insertion sequences

Rémy A Bonnin, Patrice Nordmann, Alessandra Carattoli, Laurent Poirel
Case Reports

Comparative genomics of IncL/M-type plasmids: evolution by acquisition of resistance genes and insertion sequences

Rémy A Bonnin et al. Antimicrob Agents Chemother. 2013 Jan.
No abstract available

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Figures

Fig 1
Fig 1
Major structural features of plasmid pNDM-OM compared to those of IncL/M-type plasmids pCTX-M3 (GenBank accession number AF550415), pEL60 (GenBank accession number AY422214), pCTX-M360 (GenBank accession number EU938349), pOXA-48a (GenBank accession number JN626286), and pNDM-HK (GenBank accession number HQ451074). White boxes indicate plasmid scaffold regions that are common among the plasmids. The tra locus is indicated within the box. Resistance genes are indicated by orange boxes, except the β-lactamase genes, which are indicated by blue boxes. Transposon-related genes (tnpA, tnpR, tnpM) and insertion sequences are indicated by red boxes. Replicase genes are indicated by purple boxes.
Fig 2
Fig 2
Schematic representation of insertions in the IncL/M backbone. A proposed backbone, namely, pEL60, is represented as in Fig. 1. pOXA48a-specific insertion and recombination are shown below the backbone, while specific insertion and recombination of pCTX-M360, pCTX-M3, pNDM-HK, and pNDM-OM are shown above the backbone. The type of modification, either transposition or recombination, is indicated in the figure.
See this image and copyright information in PMC

References

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