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. 2012 Oct;63(4):334-9.
doi: 10.4097/kjae.2012.63.4.334. Epub 2012 Oct 12.

The comparative study to evaluate the effect of palonosetron monotherapy versus palonosetron with dexamethasone combination therapy for prevention of postoperative nausea and vomiting

Jung Woo Park  1 , Jin Woo Jun, Yun Hee Lim, Sang Seok Lee, Byung Hoon Yoo, Kye-Min Kim, Jun Heum Yon, Ki Hyuk Hong
Affiliations

The comparative study to evaluate the effect of palonosetron monotherapy versus palonosetron with dexamethasone combination therapy for prevention of postoperative nausea and vomiting

Jung Woo Park et al. Korean J Anesthesiol. 2012 Oct.

Abstract

Background: 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are effective and safe on postoperative nausea and vomiting (PONV). Palonosetron, the newest 5-HT3 antagonist, has potent antiemetic property. We hypothesized that a combination of palonosetron and dexamethasone could more decrease PONV than palonosetron alone.

Methods: Among the patients scheduled to undergo laparoscopic gynecologic surgery, mastoidectomy with tympanoplasty or thyroidectomy under general anesthesia, eighty four female patients with at least two PONV risk factors were enrolled in this study. They were received randomly 0.075 mg palonosetron and 4 mg dexamethasone (group C) or 0.075 mg palonosetron alone (group P). The severity of PONV using Rhodes index and the percentage of complete response during postoperative 24 hours were compared between groups.

Results: The frequency of mild/moderate/great/severe PONV based on Rhodes index were 9.8%/0%/0%/0% and 9.3%/2.3%/2.3%/0% in group P and group C, respectively. Complete response for PONV was observed in 90.2% and 86% of patients in group P and group C, respectively. The overall incidence of PONV in group P and C was 9.8% and 14%, respectively. There was no significant difference between the two groups.

Conclusions: There were no differences between palonosetron monotherapy and combination therapy of palonosetron and dexamethasone in patients with high emetogenic risk.

Keywords: Dexamethasone; PONV; Palonosetron.

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Figures

Fig. 1
Fig. 1
The complete response (no emesis and no rescue medications) rate of postoperative nausea and vomiting. In group P, 0.075 mg of palonosetron was administered. In group C, 0.075 mg of palonosetron and 4 mg of dexamethasone were administered. There are no statistically significant differences between groups at 0-2 hour, 2-24 hour, 0-24 hour (P > 0.05).
See this image and copyright information in PMC

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