Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2012 Nov 1;186(9):822-3.
doi: 10.1164/rccm.201208-1500ED.

Treatment of Mycobacterium abscessus: all macrolides are equal, but perhaps some are more equal than others

Jason E Stout, R Andres Floto
Editorial

Treatment of Mycobacterium abscessus: all macrolides are equal, but perhaps some are more equal than others

Jason E Stout et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Mechanism of macrolide action and inducible macrolide resistance. (A) Macrolide antibiotics bind to the 23S ribosomal RNA, preventing bacterial protein synthesis. Expression of erm (erythromycin resistance methylase) proteins in response to macrolides leads to modification of their ribosomal binding site and induction of macrolide resistance. (B) Induction of erm(41) and subsequent macrolide resistance is greater after exposure to clarithromycin (CLR) than to azithromycin (AZM) in Mycobacterium abscessus subspecies. However, neither macrolide can induce resistance in M. massiliense, because it carries a defective erm(41) gene.
See this image and copyright information in PMC

Comment on

References

    1. Chan ED, Bai X, Kartalija M, Orme IM, Ordway DJ. Host immune response to rapidly growing mycobacteria, an emerging cause of chromic lung disease. Am J Respir Cell Mol Biol 2010;43:387–393 - PubMed
    1. Thomson RM. Changing epidemiology of pulmonary nontuberculous mycobacteria infections. Emerg Infect Dis 2010;16:1576–1583 - PMC - PubMed
    1. Lai CC, Tan CK, Chou CH, Hsu HL, Liao CH, Huang YT, Yang PC, Luh KT, Hsueh PR. Increasing incidence of nontuberculous mycobacteria, Taiwan, 2000–2008. Emerg Infect Dis 2010;16:294–296 - PMC - PubMed
    1. Prevots DR, Shaw PA, Strickland D, Jackson LA, Raebel MA, Blosky MA, Montes de Oca R, Shea YR, Seitz AE, Holland SM, et al. Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. Am J Respir Crit Care Med 2010;182:970–976 - PMC - PubMed
    1. Jarand J, Levin A, Zhang L, Huitt G, Mitchell JD, Daley CL. Clinical and microbiologic outcomes in patients receiving treatment for mycobacterium abscessus pulmonary disease. Clin Infect Dis 2011;52:565–571 - PubMed