Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012;2(3):194-200.
Epub 2012 Oct 20.

Gastrointestinal malignant lymphoma: a pathologic study of 37 cases in a single Japanese institution

Tadashi Terada  1
Affiliations

Gastrointestinal malignant lymphoma: a pathologic study of 37 cases in a single Japanese institution

Tadashi Terada. Am J Blood Res. 2012.

Abstract

The author reviewed pathologic features of 37 cases of malignant lymphoma in the gastrointestinal organs in the last 10 years in our pathology laboratory. The current WHO classification was adopted. The 37 cases consisted of 20 males and 17 female, and the age ranged from 46 to 89 years with a median of 69 years. Of the 37 cases, 25 cases (68%) were gastric lymphomas, 6 cases (16%) were small intestinal lymphomas, and 6 cases (16%) were colon lymphomas. Of the 37 cases, 35 cases (95%) were B-cell neoplasms and 2 cases (5%) were T-cell neoplasms. In the 25 gastric lymphomas (male:female=14:11, age range 46-84 years, median 70 years) 11 cases were diffuse large B-cell lymphomas, and 14 cases were extranodal marginal zone B-cell lymphomas (MALT lymphomas). The clinical endoscopic diagnosis was gastritis in 3, gastric ulcer in 3, gastric carcinoma in 7, carcinoid in 1, submucosal tumor in 1, malignant lymphoma in 2, and suspected MALT lymphoma in 8. In the 6 small intestinal lymphomas (male:female=2:4, age range 49-89 years, median 70 years), all cases were located in the ileum. Of the 6 cases, 4 were diffuse large B-cell lymphoma and 2 were peripheral T-cell lymphoma. One case showed multiple lymphomas, and one case was associated with rectal adenocarcinoma and one case with gastric MALT lymphoma. The clinical diagnosis was adenocarcinoma in 2, suspected lymphoma in 2, and ileal tumor in 2. In the 6 colon lymphomas (male:female=4:2, age range 69-86 years, median 74 years), 5 cases were diffuse large B-cell lymphomas and one case was follicular lymphoma. Clinical endoscopic diagnosis was GIST in 1, colon carcinoma in 4, and colon polyp in 1. Cases of Hodgkin's disease, mantle cell lymphoma, Burkitt lymphoma were not recognized in the present series. In summary, the author reported pathologic features of 37 cases of gastrointestinal malignant lymphoma in our laboratory in the last 10 years.

Keywords: Malignant lymphoma; gastrointestinal organs.

PubMed Disclaimer

Figures

Figure 1
Figure 1
MALT lymphoma of the stomach. A: Centrocyte-like neoplastic cell proliferation is recognized. HE x40. B: Lymphoepithelial lesions are seen. HE x200.
Figure 2
Figure 2
Diffuse large B-cell lymphoma of terminal ileum. A: Gross features indicate ulcerated large tumor (arrow). B: Low power view of the lymphoma. HE x20. C: Tumor cells have vesicular hyperchromatic nuclei and nucleoli. HE x200. D: Tumor cells are positive for CD20. Immunostaining x200.
Figure 3
Figure 3
Peripheral T-cell lymphoma of the small intestine. A: Tumor cells with atypia. HE x200. B: Tumor cells arepositive for CD3. Immunostaining, x200.
Figure 4
Figure 4
Follicular lymphoma of the colon. A: multiple polyps (arrows) are present. B: The polyp consists of lymphoid proliferation of follicular pattern. HE, x100. C: The follicles are positive for bcl-2. Immunostaining, x100.
See this image and copyright information in PMC

References

    1. Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. WHO classification of tumours. Pathology and genetics of tumours of hematopoietic and lymphoid tissues. Ryon: IARC press; 2001.
    1. Wotherspoon A, Chott A, Gascoyne RD, Muller-Hermelink HK. Lymphomas of the stomach. In: Hamilton SR, Asltonen , editors. WHO Classification of tumours. Pathology and genetics of tumours of the digestive system. Ryon: IARC press; 2000. pp. 57–61.
    1. Gascoyne RD, Muller-Hermelink HK, Chott A, Wotherspoon A. B-cell lymphoma of the small intestine. In: Hamilton SR, Asltonen , editors. WHO Classification of tumours. Pathology and genetics of tumours of the digestive system. Ryon: IARC press; 2000. pp. 83–86.
    1. Gascoyne RD, Muller-Hermelink HK, Chott A, Wotherspoon A. Intestinal T-cell lymphoma. In: Hamilton SR, Asltonen , editors. WHO Classification of tumours. Pathology and genetics of tumours of the digestive system. Ryon: IARC press; 2000. pp. 87–89.
    1. Muller-Hermelink HK, Chott A, Gascoyne RD, Wotherspoon A. B-cell lymphoma of the colon and rectum. In: Hamilton SR, Asltonen , editors. WHO Classification of tumours. Pathology and genetics of tumours of the digestive system. Ryon: IARC press; 2000. pp. 139–141.

LinkOut - more resources