Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Oct;58(4):360-3.
doi: 10.1007/BF03049595.

Chemoradiotherapy for advanced head and neck cancer - Analysis of a prospective, randomized trial

D Mitra  1 , S Basu, A R Deb, M A Rashid, P K Sur
Affiliations

Chemoradiotherapy for advanced head and neck cancer - Analysis of a prospective, randomized trial

D Mitra et al. Indian J Otolaryngol Head Neck Surg. 2006 Oct.

Abstract

Objective: To study the efficacy of neo-adjuvant chemotherapy followed by radiotherapy in advanced head and neck cancer.

Study design: Randomised, prospective study.

Setting: Tertiary academic referral center.

Patients: One hundred and eighty patients of advanced head and neck squamous cell carcinoma.

Intervention: PATIENTS were randomized into two arms. The study arm (CT-RT arm) received 3 cycles of anterior chemotherapy with Inj. Cisplatin 100 mg/m(2) on D(1) and Inj 5F.U. 700 mg/m(2) on D(1)-D(4) at an interval of 21 days, followed by external radiation. The control arm (RT arm) received external radiotherapy only. The dose of Radiotherapy was 64 to 68 Gy in conventional fractionation.

Results: PATIENTS of CT-RT showed better tumour control locally than patients who received only RT. Toxicities were commoner in CT-RT arm but they were manageable. 5 year survival is higher in the CT-RT arm (21% vs 16%; p value> 0.05).

Conclusion: Anterior chemotherapy with Cisplatin and 5F.U. is associated with good clinical response which is translated into increased survival along with acceptable toxicities.

Keywords: Cisplatin and 5F.U.; Head & Neck Cancer; Neo-adjuvant Chemotherapy.

PubMed Disclaimer

References

    1. Nandakumar A. National Cancer Registry Programme. Bangalore: ICMR; 2001.
    1. Aisner J, Jacobs M, Sinabaldi V, Gray W, Eisenberger M, et al. Chemoradiotherapy for the treatment of regionally advanced head and neck cancer by. Semin Oncol. 1994;21:35–44. - PubMed
    1. Saraf m Al. Cisplatin combination in the treatment of head and neck cancer. Semin-Onkol. 1994;21(5):28–34. - PubMed
    1. Chougule P B, Akhtar M.S., Akerley W, et al. Chemoradiotherapy for advanced inoperable head and neck cancer. A phase II study Semi Radiat Oncol. 1999;9:58–63. - PubMed
    1. Harrari P M. Why has induction chemotherapy for advanced head and neck cancer become a United States community standard of practice? Journal of Clinical Oncology. 1997;15(5):2050–55. - PubMed

LinkOut - more resources