Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec;18(12):988-93.
doi: 10.1111/cns.12021. Epub 2012 Nov 2.

One-year clinical prediction in Chinese ischemic stroke patients using the CHADS2 and CHA2DS2-VASc scores: the China National Stroke Registry

Shu-Ya Li  1 , Xing-Quan Zhao, Chun-Xue Wang, Li-Ping Liu, Gai-Fen Liu, Yi-Long Wang, Yong-Jun Wang
Affiliations

One-year clinical prediction in Chinese ischemic stroke patients using the CHADS2 and CHA2DS2-VASc scores: the China National Stroke Registry

Shu-Ya Li et al. CNS Neurosci Ther. 2012 Dec.

Abstract

Aims: We investigated whether CHADS2 or CHA2DS2-VASc scores could be used to predict 1-year prognosis in stroke recurrence, mortality, and mortality of ischemic stroke or transient ischemic attack (TIA) patients with nonvalvular atrial fibrillation (NVAF).

Methods: Patients were selected from a national prospective registry in China. The clinical prediction of the scores was examined using the C statistic. Univariate and multivariate logistic regressions were performed to analyze the relevant risk factors.

Results: Thousand two hundred and ninety-seven of 22,216 patients were enrolled in the study. For stroke recurrence rate, the C statistic value was 0.53 (odds ratio [OR] 1.15, 95% confidence interval [CI]: 1.01 to 1.32) for CHADS2 and 0.55 (OR 1.14, 95% CI: 1.05 to 1.24) for CHA2DS2-VASc; adding baseline National Institutes of Health Stroke Scale (NIHSS) score to these two scores, the value of C statistic was 0.58 (OR 1.25 95% CI: 1.14 to 1.37) and 0.58 (OR 1.19, 95% CI: 1.11 to 1.27), respectively.

Conclusions: Both CHADS2 and CHA2DS2-VASc scores have limitations in predicting the 1-year prognosis of stroke/TIA patients with NVAF in China. The predictive value of these two scores improved by adding the baseline NIHSS score.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of study population. Abbreviation: IS, ischemic stroke, TIA, transient ischemic attack, AF, atrial fibrillation.
See this image and copyright information in PMC

References

    1. Ihle‐Hansen H, Thommessen B, Wyller TB, Engedal K, Fure B. Risk factors for and incidence of subtypes of ischemic stroke. Funct Neurol 2012;27:35–40. - PMC - PubMed
    1. Lin S, Wu B, Hao ZL, et al. Characteristics, treatment and outcome of ischemic stroke with atrial fibrillation in a chinese hospital‐based stroke study. Cerebrovasc Dis 2011;31:419–426. - PubMed
    1. Wen‐Hang QI. Retrospective investigation of hospitalised patients with atrial fibrillation in mainland china. Int J Cardiol 2005;105:283–287. - PubMed
    1. Gage BF, Waterman AD, Shannon W, Boechler M, Rich MW, Radford MJ. Validation of clinical classification schemes for predicting stroke: Results from the national registry of atrial fibrillation. JAMA 2001;285:2864–2870. - PubMed
    1. Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor‐based approach: The euro heart survey on atrial fibrillation. Chest 2010;137:263–272. - PubMed

Publication types

MeSH terms