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Comment
. 2012 Nov 2;11(5):583-4.
doi: 10.1016/j.stem.2012.10.007.

Stressed out: endogenous aldehydes damage hematopoietic stem cells

Kalindi Parmar  1 , Alan D D'Andrea
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Free article
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Stressed out: endogenous aldehydes damage hematopoietic stem cells

Kalindi Parmar et al. Cell Stem Cell. .
Free article

Abstract

Despite a well-defined role for the Fanconi anemia (FA) pathway in mediating DNA repair, the mechanisms underlying the bone marrow failure in FA patients are poorly defined. Recently in Nature, Garaycoechea et al. (2012), identify aldehyde-mediated genotoxicity of hematopoietic stem cells as a cause for bone marrow failure.

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