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. 2013 Jan;78(1):1-7.
doi: 10.1016/j.steroids.2012.10.001. Epub 2012 Nov 2.

Cytotoxic steroidal saponins from Ophiopogon japonicus

Ning Li  1 , Liang Zhang, Ke-Wu Zeng, Yuan Zhou, Jia-Yu Zhang, Yan-Yun Che, Peng-Fei Tu
Affiliations

Cytotoxic steroidal saponins from Ophiopogon japonicus

Ning Li et al. Steroids. 2013 Jan.

Abstract

Four new steroidal saponins, named ophiopogonin P-S (1-4), together with eleven known ones (5-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analysis. Compounds 2-15 were evaluated for their cytotoxic activity against five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela). Compounds 2, 5, 6, 8 and 9 were cytotoxic for all cell lines tested. Compounds 7, 11 and 15 showed selective cytotoxicity against some of the cell lines. The structure-activity relationship of these compounds was discussed.

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