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Randomized Controlled Trial
. 2013 Jan;8(1):82-9.
doi: 10.2215/CJN.00010112. Epub 2012 Nov 2.

Effect of hemodiafiltration on quality of life over time

Albert H A Mazairac  1 , G Ardine de Wit, Muriel P C Grooteman, E Lars Penne, Neelke C van der Weerd, Claire H den Hoedt, Renée Lévesque, Marinus A van den Dorpel, Menso J Nubé, Piet M ter Wee, Michiel L Bots, Peter J Blankestijn; CONTRAST Investigators
Collaborators, Affiliations
Randomized Controlled Trial

Effect of hemodiafiltration on quality of life over time

Albert H A Mazairac et al. Clin J Am Soc Nephrol. 2013 Jan.

Abstract

Background and objectives: It is unclear if hemodiafiltration leads to a better quality of life compared with hemodialysis. It was, therefore, the aim of this study to assess the effect of hemodiafiltration on quality of life compared with hemodialysis in patients with ESRD.

Design, setting, participants, & measurements: This study analyzed the data of 714 patients with a median follow-up of 2 years from the Convective Transport Study. The patients were enrolled between June of 2004 and December of 2009. The Convective Transport Study is a randomized controlled trial on the effect of online hemodiafiltration versus low-flux hemodialysis on all-cause mortality. Quality of life was assessed with the Kidney Disease Quality of Life-Short Form. This questionnaire provides data for a physical and mental composite score and describes kidney disease-specific quality of life in 12 domains. The domains have scales from 0 to 100.

Results: There were no significant differences in changes in health-related quality of life over time between patients treated with hemodialysis (n=358) or hemodiafiltration (n=356). The quality of life domain patient satisfaction declined over time in both dialysis modalities (hemodialysis: -2.5/yr, -3.4 to -1.5, P<0.001; hemodiafiltration: -1.4/yr, -2.4 to -0.5, P=0.004).

Conclusions: Compared with hemodialysis, hemodiafiltration had no significant effect on quality of life over time.

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Figures

Figure 1.
Figure 1.
Patient flow diagram. Because patients were included at different points in time, potential follow-up time varies per patient. The median follow-up of these patients was 2.0 years (interquartile range=1.1–3.0). The line between consecutive years of follow-up is dashed to point out that a measurement was sometimes skipped (e.g., 17 patients did not fill out the KDQOL-SF at baseline but did fill it out after 1 year of follow-up). HD, hemodialysis; HDF, hemodiafiltration; HRQOL, health-related quality of life; KDQOL-SF, Kidney Disease Quality of Life—Short Form; PD, peritoneal dialysis.
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