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Review
. 2012 Nov 1;4(11):a011254.
doi: 10.1101/cshperspect.a011254.

MAP kinase pathways

Deborah K Morrison  1
Affiliations
Review

MAP kinase pathways

Deborah K Morrison. Cold Spring Harb Perspect Biol. .

Abstract

MAP kinases are activated within protein kinase cascades that regulate cell proliferation, differentiation, and death. In mammals, MAP kinases are grouped into three families: ERKs, JNKs, and p38/SAPKs.

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Figures

Figure 1.
Figure 1.
MAPK pathways.
Figure 2.
Figure 2.
The ERK MAPK pathway.
Figure 3.
Figure 3.
The JNK MAPK pathway.
Figure 4.
Figure 4.
The p38 MAPK pathway.
See this image and copyright information in PMC

References

    1. Bardwell L, Thorner J 1996. A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs. Trends Biochem Sci 21: 373–374 - PubMed
    1. Cuadrado A, Nebreda AR 2010. Mechanisms and functions of p38 MAPK signalling. Biochem J 429: 403–417 - PubMed
    1. Cuenda A, Rousseau S 2007. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 1773: 1358–1375 - PubMed
    1. Cuevas BD, Abell AN, Johnson GL 2007. Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene 26: 3159–3171 - PubMed
    1. Dhanasekaran DN, Reddy EP 2008. JNK signaling in apoptosis. Oncogene 27: 6245–6251 - PMC - PubMed

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