Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Nov 1;2(11):a011585.
doi: 10.1101/cshperspect.a011585.

Alzheimer disease in 2020

David M Holtzman  1 , Eckhard Mandelkow, Dennis J Selkoe
Affiliations
Review

Alzheimer disease in 2020

David M Holtzman et al. Cold Spring Harb Perspect Med. .

Abstract

Remarkable advances in unraveling the biological underpinnings of Alzheimer disease (AD) have occurred during the last 25 years. Despite this, we have made only the smallest of dents in the development of truly disease-modifying treatments. What will change over the next 10 years? While the answer is not clear, we make several predictions on the state of the field in 2020, based on the rich knowledge described in the other contributions in this collection. As such, our predictions represent some of the principal unresolved questions that we believe deserve special investigative attention in the coming decade.

PubMed Disclaimer

References

    1. Aisen PS, Cummings J, Schneider LS 2011. Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease. Cold Spring Harb Perspect Med 10.1101/cshperspect.a006395 - DOI - PMC - PubMed
    1. Lee VM-Y, Brunden KR, Hutton M, Trojanowski JQ 2011. Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets. Cold Spring Harb Perspect Med 10.1101/cshperspect.a006437 - DOI - PMC - PubMed
    1. Schenk D, Basi GS, Pangalos MN 2011. Treatment strategies targeting amyloid β-protein. Cold Spring Harb Pespect Med 10.1101/cshperspect.a006387 - DOI - PMC - PubMed