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. 2013 Mar;28(2):104-13.
doi: 10.1093/arclin/acs098. Epub 2012 Nov 4.

Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy

Adam Gerstenecker  1 , Benjamin Mast, Kevin Duff, Tanis J Ferman, Irene Litvan; ENGENE-PSP Study Group
Affiliations

Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy

Adam Gerstenecker et al. Arch Clin Neuropsychol. 2013 Mar.

Abstract

Cognitive difficulties appear to be a more prevalent clinical feature in progressive supranuclear palsy (PSP) than previously thought, and significant cognitive impairment is prevalent in a majority of patients PSP patients not considered clinically demented. The neurocognitive performance of 200 patients with PSP across multiple sites was examined with a variety of commonly used neuropsychological tests. Results indicate primary executive dysfunction (e.g., 74% impaired on the Frontal Assessment Battery, 55% impaired on Initiation/Perseveration subscale of the Dementia Rating Scale), with milder difficulties in memory, construction, and naming. These results have important clinical implications for providers following patients with PSP.

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