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Randomized Controlled Trial
. 2013 Feb;70(2):183-90.
doi: 10.1001/jamaneurol.2013.646.

Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease

Lisa M Shulman  1 , Leslie I Katzel, Frederick M Ivey, John D Sorkin, Knachelle Favors, Karen E Anderson, Barbara A Smith, Stephen G Reich, William J Weiner, Richard F Macko
Affiliations
Randomized Controlled Trial

Randomized clinical trial of 3 types of physical exercise for patients with Parkinson disease

Lisa M Shulman et al. JAMA Neurol. 2013 Feb.

Abstract

Objective: To compare the efficacy of treadmill exercises and stretching and resistance exercises in improving gait speed, strength, and fitness for patients with Parkinson disease.

Design: A comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise.

Setting: The Parkinson's Disease and Movement Disorders Center at the University of Maryland and the Baltimore Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center.

Patients: A total of 67 patients with Parkinson disease who had gait impairment were randomly assigned to 1 of 3 arms of the trial. INTERVENTIONS; (1) A higher-intensity treadmill exercise (30 minutes at 70%-80% of heart rate reserve), (2) a lower-intensity treadmill exercise (50 minutes at 40%-50% of heart rate reserve), and (3) stretching and resistance exercises (2 sets of 10 repetitions on each leg on 3 resistance machines [leg press, leg extension, and curl]). These exercises were performed 3 times a week for 3 months.

Main outcome measures: The primary outcome measures were gait speed (6-minute walk), cardiovascular fitness (peak oxygen consumption per unit time [$$ VO2], and muscle strength (1-repetition maximum strength).

Results: All 3 types of physical exercise improved distance on the 6-minute walk: lower-intensity treadmill exercise (12% increase; P=.001), stretching and resistance exercises (9% increase; P<.02), and higher-intensity treadmill exercise (6% increase; P=.07), with no between-group differences. Both treadmill exercises improved peak $$ VO2 (7%-8% increase; P<.05) more than did the stretching and resistance exercises. Only stretching and resistance improved muscle strength (16% increase; P<.001).

Conclusions: The effects of exercise were seen across all 3 exercise groups. The lower-intensity treadmill exercise resulted in the greatest improvement in gait speed. Both the higher- and lower-intensity treadmill exercises improved cardiovascular fitness. Only the stretching and resistance exercises improved muscle strength. Therefore, exercise can improve gait speed, muscle strength, and fitness for patients with Parkinson disease. The combination of treadmill and resistance exercises may result in greater benefit and requires further investigation.

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Figures

Figure
Figure
Consolidated Standards for Reporting Trials flow diagram of comparative, prospective, randomized, single-blinded clinical trial of 3 types of physical exercise for participants with Parkinson disease. DBS indicates deep brain stimulation; HIT, higher-intensity treadmill; LIT, lower-intensity treadmill, S-R, stretching and resistance.
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References

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