Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Apr;1(2):e000364.
doi: 10.1161/JAHA.111.000364. Epub 2012 Apr 24.

Updates in cardiac amyloidosis: a review

Sanjay M Banypersad  1 , James C Moon, Carol Whelan, Philip N Hawkins, Ashutosh D Wechalekar
Affiliations

Updates in cardiac amyloidosis: a review

Sanjay M Banypersad et al. J Am Heart Assoc. 2012 Apr.
No abstract available

Keywords: cardiac amyloidosis; infiltrative cardiomypathy; treatment.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
ECG of a patient with cardiac AL amyloidosis showing small QRS voltages (defined as ≤6 mm height), predominantly in the limb leads and pseudoinfarction pattern in the anterior leads.
Figure 2.
Figure 2.
Transthoracic echocardiogram with speckle tracking. The red and yellow lines represent longitudinal motion in the basal segments, whereas the purple and green lines represent apical motion. This shows loss of longitudinal ventricular contraction at the base compared to apex.
Figure 3.
Figure 3.
CMR with the classic amyloid global, subendocardial late gadolinium enhancement pattern in the left ventricle with blood and mid-/epimyocardium nulling together.
Figure 4.
Figure 4.
Sequential static images from a CMR TI scout sequence. As the inversion time (TI) increases, myocardium nulls first (arrow in image 3), followed by blood afterwards (arrow in image 6), implying that there is more gadolinium contrast in the myocardium than blood—a degree of interstitial expansion such that the “myocrit” is smaller than the hematocrit.
Figure 5.
Figure 5.
A positive 99mTc-DPD scan for TTR cardiac amyloid (left), showing uptake in the heart (arrow) and reduced bone uptake. The right-hand panel shows a fused CT/SPECT image showing myocardial uptake with greater uptake in the septum.
Figure 6.
Figure 6.
An endomyocardial biopsy of a patient with cardiac AL amyloidosis stained as follows: (A) Congo red only; (B) Apple-green birefringence under polarized light; (C) Congo red with lambda overlay (negative); (D) Congo red with kappa overlay (positive).
See this image and copyright information in PMC

References

    1. Falk RH. Diagnosis and management of the cardiac amyloidoses. Circulation. 2005;112:2047-2060 - PubMed
    1. Gutierrez PS, Fernandes F, Mady C, Higuchi Mde L. Clinical, electrocardiographic and echocardiographic findings in significant cardiac amyloidosis detected only at necropsy: comparison with cases diagnosed in life. Arq Bras Cardiol. 2008;90:191-196 - PubMed
    1. Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ, Minogue S, Dhillon AP, Taylor GW, Bradwell AR, Petrie A, Gillmore JD, Bellotti V, Botto M, Hawkins PN, Pepys MB. Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature. 2010;468:93-97 - PMC - PubMed
    1. Westermark P, Benson MD, Buxbaum JN, Cohen AS, Frangione B, lkeda S, Masters CL, Merlini G, Saraiva MJ, Sipe JD. A primer of amyloid nomenclature. Amyloid. 2007;14:179-183 - PubMed
    1. Sipe JD, Benson MD, Buxbaum JN, Ikeda S, Merlini G, Saraiva MJ, Westermark P. Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis. Amyloid. 2010;17:101-104 - PubMed

LinkOut - more resources