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. 2012 Apr;1(2):e001412.
doi: 10.1161/JAHA.112.001412. Epub 2012 Apr 24.

Genetic silencing of pacemaker cells: local intervention with global implications

Caline S Karam  1 , Fadi G Akar
Affiliations

Genetic silencing of pacemaker cells: local intervention with global implications

Caline S Karam et al. J Am Heart Assoc. 2012 Apr.
No abstract available

Keywords: Ivabradine; biological pacemaker; gene therapy; heart failure; heart rate.

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References

    1. Lugenbiel PBA, Kelemen K, Schweizer PA, Becker R, Katus HA, Thomas D. biological heart rate reduction through genetic supression of Galphas protein in the sinoatrial node. J Am Heart Assoc. 2012;1:e000372.doi: 10.1161/JAHA.111.000372 - DOI - PMC - PubMed
    1. Ekman I, Chassany O, Komajda M, Bohm M, Borer JS, Ford I, Tavazzi L, Swedberg K. Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study. Eur Heart J. 2010;32:2395-2404 - PubMed
    1. Akar FG, Nass RD, Hahn S, Cingolani E, Shah M, Hesketh GG, DiSilvestre D, Tunin RS, Kass DA, Tomaselli GF. Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. Am J Physiol. 2007;293:H1223-H1230 - PubMed
    1. Shinagawa K, Shi YF, Tardif JC, Leung TK, Nattel S. Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs. Circulation. 2002;105:2672-2678 - PubMed
    1. Pickworth KK. Long-term dobutamine therapy for refractory congestive heart failure. Clin Pharm. 1992;11:618-624 - PubMed

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