Studies on comparison of the efficacy of terbinafine 1% cream and butenafine 1% cream for the treatment of Tinea cruris
- PMID: 23130183
- PMCID: PMC3481417
- DOI: 10.4103/2229-5178.73249
Studies on comparison of the efficacy of terbinafine 1% cream and butenafine 1% cream for the treatment of Tinea cruris
Abstract
Background: In this study, 76 male patients aged between 18 and 61 years affected with Tinea cruris attending the outpatient department of NRS Medical College during a 1-year period were selected.
Materials and methods: The patients were divided into two groups as Regimen I (n 37) and Regimen II (n 39) who were treated with Terbinafine (gr I) cream and Butenafine (gr II) cream, respectively.
Results: The predominant pathogen was found to be Trichophyton rubrum in 99% of cases. Mycological cure, overall cure and effective treatment were evaluated on 7, 14 and 42 days.
Conclusions: From the study, it was found that Butenafine produced the quickest result and primary efficacy end points were much higher with Butenafine cream than that of Terbinafine cream and this difference was statistically significant (P < 0.01).
Keywords: Tinea cruris; butenafine cream; terbinafine cream.
Conflict of interest statement
Similar articles
-
Efficacy and Safety of Terbinafine Hydrochloride 1% Cream vs. Sertaconazole Nitrate 2% Cream in Tinea Corporis and Tinea Cruris: A Comparative Therapeutic Trial.Indian J Dermatol. 2013 Nov;58(6):457-60. doi: 10.4103/0019-5154.119958. Indian J Dermatol. 2013. PMID: 24249898 Free PMC article.
-
Once daily treatment with terbinafine 1% cream (Lamisil) for one week is effective in the treatment of tinea corporis and cruris. A placebo-controlled study.Mycoses. 2001;44(7-8):300-6. Mycoses. 2001. PMID: 11714065 Clinical Trial.
-
Efficacy and safety of terbinafine hydrochloride 1% cream vs eberconazole nitrate 1% cream in localised tinea corporis and tinea cruris.Indian Dermatol Online J. 2014 Apr;5(2):128-31. doi: 10.4103/2229-5178.131079. Indian Dermatol Online J. 2014. PMID: 24860743 Free PMC article.
-
Terbinafine. An update of its use in superficial mycoses.Drugs. 1999 Jul;58(1):179-202. doi: 10.2165/00003495-199958010-00018. Drugs. 1999. PMID: 10439936 Review.
-
Butenafine.Drugs. 1998 Mar;55(3):405-12; discussion 413. doi: 10.2165/00003495-199855030-00006. Drugs. 1998. PMID: 9530545 Review.
Cited by
-
Allylamines, Benzylamines, and Fungal Cell Permeability: A Review of Mechanistic Effects and Usefulness against Fungal Pathogens.Membranes (Basel). 2022 Nov 22;12(12):1171. doi: 10.3390/membranes12121171. Membranes (Basel). 2022. PMID: 36557078 Free PMC article. Review.
-
Treatment of superficial mycoses: review. Part II.An Bras Dermatol. 2013 Nov-Dec;88(6):937-44. doi: 10.1590/abd1806-4841.20132018. An Bras Dermatol. 2013. PMID: 24474103 Free PMC article. Review.
-
Efficacy and tolerability of topical sertaconazole versus topical terbinafine in localized dermatophytosis: A randomized, observer-blind, parallel group study.Indian J Pharmacol. 2016 Nov-Dec;48(6):659-664. doi: 10.4103/0253-7613.194850. Indian J Pharmacol. 2016. PMID: 28066103 Free PMC article. Clinical Trial.
-
Newer Topical Treatments in Skin and Nail Dermatophyte Infections.Indian Dermatol Online J. 2018 May-Jun;9(3):149-158. doi: 10.4103/idoj.IDOJ_281_17. Indian Dermatol Online J. 2018. PMID: 29854633 Free PMC article. Review.
-
Clinical, epidemiological, and therapeutic profile of dermatophytosis.An Bras Dermatol. 2014 Mar-Apr;89(2):259-64. doi: 10.1590/abd1806-4841.20142569. An Bras Dermatol. 2014. PMID: 24770502 Free PMC article.
References
-
- Kanwar AJ, Mamta, Chander J. Superficial fungal infection. In: Valia RG, Valia AR, Siddappa K, editors. Textboob and Atlas of Dermatology. 2nd ed. Bhalani Publishing House: Mumbai India; 2001. pp. 215–58.
-
- Pierard GE, Arrese JE, Pierard-Franchimont C. Treatment and prophylaxis of tinea infections. Drugs. 1996;52:209–24. - PubMed
-
- Ryder NS. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992;126:2–7. - PubMed
-
- Fukushiro R, Urabe H, Kagawa S. Recent progress in antifungal therapy. In: Yamaguchi H, Kobayashi GS, Takahashi H, editors. Butenafine hydrochloride, a new antifungal agent: clinical and experimental study. Marcel Dekker: New York; 1992. pp. 147–57.
-
- Rathi SK. Comparative efficacy of 1% terbinafine hydrochloride and 1% butenafine hydrochloride cream in the treatment of tinea cruris. Indian J Dermatol. 2001;46:227–8.