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. 2010 Jul;1(1):8-9.
doi: 10.4103/2229-5178.73249.

Studies on comparison of the efficacy of terbinafine 1% cream and butenafine 1% cream for the treatment of Tinea cruris

Sudip Das  1 , J N Barbhuniya, Indranil Biswas, S Bhattacharya, P K Kundu
Affiliations

Studies on comparison of the efficacy of terbinafine 1% cream and butenafine 1% cream for the treatment of Tinea cruris

Sudip Das et al. Indian Dermatol Online J. 2010 Jul.

Abstract

Background: In this study, 76 male patients aged between 18 and 61 years affected with Tinea cruris attending the outpatient department of NRS Medical College during a 1-year period were selected.

Materials and methods: The patients were divided into two groups as Regimen I (n 37) and Regimen II (n 39) who were treated with Terbinafine (gr I) cream and Butenafine (gr II) cream, respectively.

Results: The predominant pathogen was found to be Trichophyton rubrum in 99% of cases. Mycological cure, overall cure and effective treatment were evaluated on 7, 14 and 42 days.

Conclusions: From the study, it was found that Butenafine produced the quickest result and primary efficacy end points were much higher with Butenafine cream than that of Terbinafine cream and this difference was statistically significant (P < 0.01).

Keywords: Tinea cruris; butenafine cream; terbinafine cream.

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Conflict of interest statement

Conflict of Interest: None declared

References

    1. Kanwar AJ, Mamta, Chander J. Superficial fungal infection. In: Valia RG, Valia AR, Siddappa K, editors. Textboob and Atlas of Dermatology. 2nd ed. Bhalani Publishing House: Mumbai India; 2001. pp. 215–58.
    1. Pierard GE, Arrese JE, Pierard-Franchimont C. Treatment and prophylaxis of tinea infections. Drugs. 1996;52:209–24. - PubMed
    1. Ryder NS. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992;126:2–7. - PubMed
    1. Fukushiro R, Urabe H, Kagawa S. Recent progress in antifungal therapy. In: Yamaguchi H, Kobayashi GS, Takahashi H, editors. Butenafine hydrochloride, a new antifungal agent: clinical and experimental study. Marcel Dekker: New York; 1992. pp. 147–57.
    1. Rathi SK. Comparative efficacy of 1% terbinafine hydrochloride and 1% butenafine hydrochloride cream in the treatment of tinea cruris. Indian J Dermatol. 2001;46:227–8.