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. 2012:2012:241816.
doi: 10.1155/2012/241816. Epub 2012 Oct 24.

Lymphoepithelioma-like carcinoma of the skin treated with wide local excision and chemoradiation therapy: a case report and review of the literature

Theresa M Gille  1 , Edward F Miles, Allen O Mitchell
Affiliations

Lymphoepithelioma-like carcinoma of the skin treated with wide local excision and chemoradiation therapy: a case report and review of the literature

Theresa M Gille et al. Case Rep Oncol Med. 2012.

Abstract

Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare cutaneous neoplasm microscopically similar to undifferentiated nasopharyngeal carcinoma. It is typically nonaggressive and is treated with wide local excision. However, we present a case of a patient with a regional recurrence and more aggressive LELCS with perineural invasion and positive margins for which he was treated with wide local excision followed by chemoradiation. We discuss the use of chemoradiation for this patient and review the literature, specifically pertaining to treatment of more aggressive cases of LELCS.

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Figures

Figure 1
Figure 1
Hematoxylin and eosin stain (100x) showed aggregates of atypical epithelial cells and associated lymphoid tissue supported by fibrous connective tissue.
Figure 2
Figure 2
Immunohistochemical staining (100x) positive for CK-5/6.
See this image and copyright information in PMC

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