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. 2012:2012:430141.
doi: 10.1155/2012/430141. Epub 2012 Oct 21.

Bortezomib-induced bronchiolitis obliterans organizing pneumonia

E Vandeix  1 , F Favard, N Pichon, M Delage-Corre, B Melloni, M Clavel
Affiliations

Bortezomib-induced bronchiolitis obliterans organizing pneumonia

E Vandeix et al. Case Rep Pulmonol. 2012.

Abstract

Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS). A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP) lesions. Systemic corticotherapy led to a rapid improvement in the patient's condition. Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.

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Figures

Figure 1
Figure 1
Postero anterior radiograph of the chest obtained on admission.
Figure 2
Figure 2
CT scan of the chest obtained on Day 1 showing diffuse bilateral alveolar infiltrate.
Figure 3
Figure 3
Open lung biopsy performed on day 6 (HES × 50): lesions of bronchiolitis obliterans with organizing fibroblastic polyps in alveoli.
Figure 4
Figure 4
Postero anterior radiograph of the chest on Day 12.
See this image and copyright information in PMC

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