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. 2012 Dec 13;55(23):10776-80.
doi: 10.1021/jm301262z. Epub 2012 Nov 15.

Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance

Paul T Bremer  1 , Kim D Janda
Affiliations

Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance

Paul T Bremer et al. J Med Chem. .

Abstract

We challenged the performance of our previous heroin vaccine with a similar vaccine containing a more hydrolytically stable hapten analogue and a Th1 adjuvant (CpG ODN). Our results indicate that the elements of our previous vaccine are essential for its anti-heroin potency, i.e., a chemically labile hapten and an exclusively Th2 humoral response elicited by alum. Such design elements are critical for producing next-generation heroin vaccines.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Heroin Immunoconjugate Structures
Scheme 1
Scheme 1
Synthesis of 3-Acetamidoheroin
Scheme 2
Scheme 2
Conjugation of thiol heroin haptens to KLH
See this image and copyright information in PMC

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