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. 2012 Nov 7;12(1):44.
doi: 10.1186/1475-2867-12-44.

The role of A20 in the pathogenesis of lymphocytic malignancy

Fan Zhang  1 , Lijiang Yang, Yangqiu Li
Affiliations

The role of A20 in the pathogenesis of lymphocytic malignancy

Fan Zhang et al. Cancer Cell Int. .

Abstract

Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequently found in lymphomas, suggesting that it may be a linker between the altered immune response and leukemogenesis. The aim of this review is to summarize current findings of the A20 biological functions and its molecular mechanism as a tumor suppressor and immune regulator. The identification of A20 mutations and deletions in lymphocytic malignancy and the predictive significance of these aberrations are also reviewed.

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Figures

Figure 1
Figure 1
Regulation of the NF‐κB signaling related A20 protein by ubiquitylation in T cells.
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