Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Sep-Oct;13(5):271-7.
doi: 10.1310/hct1305-271.

Feasibility and reliability of interactive voice response assessment of HIV medication adherence: research and clinical implications

Jennifer E Hettema  1 , Sharzad Hosseinbor, Karen S Ingersoll
Affiliations

Feasibility and reliability of interactive voice response assessment of HIV medication adherence: research and clinical implications

Jennifer E Hettema et al. HIV Clin Trials. 2012 Sep-Oct.

Abstract

Background: There are well-documented negative consequences of nonadherence to HIV medications. Telephone-based interactive voice response (IVR) technologies may hold promise for assessing nonadherence in both research and clinical contexts; however, little psychometric research has been conducted on this topic.

Objective: In the present pilot study, we test the feasibility and reliability of a simplified patient-initiated, daily IVR system with a convenience sample of HIV patients attending a university-affiliated infectious disease clinic.

Methods: Participants were asked to call in to an IVR system to report adherence daily during 2 weeks of a larger prospective study. Response rates and patterns were analyzed for feasibility and compared to retrospective, self-report timeline follow-back (TLFB) adherence reporting.

Results: The IVR protocol showed moderate feasibility, with participants reporting adherence behavior on 63.4% of days. However, agreement with TLFB data was low, particularly for days in which participants reported incomplete adherence.

Conclusions: The IVR protocol tested in the current trial shows some promise. Completion rates were higher than in previous trials. Future research is needed to further enhance the feasibility of IVR for HIV medication adherence and to compare responses to more objective measures on HIV adherence.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Agreement or disagreement between timeline follow-back (TFLB) and telephone reporting system (TRS) total adherence rates in terms of number of participants.
Figure 2
Figure 2
Agreement or disagreement between timeline follow-back (TFLB) and telephone reporting system (TRS) daily adherence rates in terms of number of days.
See this image and copyright information in PMC

References

    1. UNAIDS . Global HIV/AIDS Response: Epidemic Update and Health Sector Progress Towards Universal Access. World Health Organization; Geneva: 2011.
    1. Nieuwkerk PT, Oort FJ. Self-reported adherence to antiretroviral therapy for HIV-1 infection and virologic treatment response: a meta-analysis. J Acquir Immune Defic Syndr. 2005;38:445–448. - PubMed
    1. Parienti JJ, Das- Douglas M, Massari V, Guzman D, Verdon R, Bangsberg DR. Not all missed doses are the same: sustained NNRTI treatment interruptions predict HIV rebound to low-to-moderate adherence levels. PLoS One. 2008;3:e2783. - PMC - PubMed
    1. Horvath T, Azman H, Kennedy GE, Rutherford GW. Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection. Cochrane Database Syst Rev. 2012;14:CD009756. - PMC - PubMed
    1. Shet A, de Costa A. India calling: harnessing the promise of mobile phones for HIV healthcare. Trop Med Int Health. 2011;16:214–216. - PubMed

Publication types