doi: 10.1039/c2cc36613d.
Epub 2012 Nov 8.
One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines
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- PMID: 23135220
- DOI: 10.1039/c2cc36613d
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One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines
Chem Commun (Camb).
.
Abstract
Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.
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