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. 2012 Dec 25;48(99):12100-2.
doi: 10.1039/c2cc36613d. Epub 2012 Nov 8.

One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

Vjekoslav Štrukil  1 , Boris Bartolec, Tomislav Portada, Ivica Đilović, Ivan Halasz, Davor Margetić
Affiliations

One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines

Vjekoslav Štrukil et al. Chem Commun (Camb). .

Abstract

Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.

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