A sweet surprise for HIV broadly neutralizing antibodies
- PMID: 23135511
- DOI: 10.1038/nm.2993
A sweet surprise for HIV broadly neutralizing antibodies
Abstract
The production of cross-reactive neutralizing antibodies is the ultimate goal in HIV vaccine development, but no immunogen other than HIV itself has been able to elicit this type of humoral immunity. In natural HIV infections, these antibodies take several years to develop. A new study sheds light on what may be causing this delay in neutralizing antibody development (pages 1688-1692).
Comment on
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Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape.Nat Med. 2012 Nov;18(11):1688-92. doi: 10.1038/nm.2985. Epub 2012 Oct 21. Nat Med. 2012. PMID: 23086475 Free PMC article.
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