Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Dec;8(4):308-11.
doi: 10.1007/s12663-009-0075-y. Epub 2010 Apr 24.

Potential for osseous regeneration of platelet rich plasma: a comparitive study in mandibular third molar sockets

G K Vivek  1 , B H Sripathi Rao
Affiliations

Potential for osseous regeneration of platelet rich plasma: a comparitive study in mandibular third molar sockets

G K Vivek et al. J Maxillofac Oral Surg. 2009 Dec.

Abstract

Purpose: To evaluate the efficacy of autologous platelet-rich plasma in soft tissue healing & bone regeneration in mandibular third molar extraction socket.

Methods: The study was conducted in 10 patients visiting the outpatient Department of Oral & Maxillofacial Surgery, requiring extraction of bilateral mandibular third molars. Following extraction, autologous Platelet Rich Plasma (PRP) was placed in one extraction socket, the other socket was studied as the control site with no PRP. The patients were assessed for postoperative pain, soft tissue healing, bone blending and trabecular formation. Radiological assessment of the extraction site was done for a period of 4 months to evaluate the change in bone density.

Results: Pain was less in the study site compared to control site, soft tissue healing was better in study site. Evaluation for bone blending and trabecular bone formation started earlier in PRP site compared to control, non PRP site. The evaluation of bone density by radiological assessment showed the grey level values calculated after 4 months at the PRP site were comparatively higher than the average baseline value of bone density at extraction site in control site.

Conclusion: The study showed that autologous PRP is biocompatible and has significantly improved soft tissue healing, bone regeneration and increase in bone density in extraction sockets. However a more elaborate study with a larger number of clinical cases is essential to be more conclusive regarding its efficacy.

Keywords: Bone density; Bone trabeculae; Mandibular third molar extract socket; Pain; Platelet rich plasma; Soft tissue healing.

PubMed Disclaimer

References

    1. Dugrillon A., Eichler H., Kern S., Kluter H. Autologous concentrated platelet-rich plasma (cPRP) for local application in bone regeneration. Int J Oral Maxillofac Surg. 2002;31(6):615–619. doi: 10.1054/ijom.2002.0322. - DOI - PubMed
    1. Landry R.G., Turnbull R.S., Howley T. Effectiveness of benzydamyne HCl in the treatment of periodontal postsurgical patients. Res Clin Forum. 1988;10:105–118.
    1. Masse J.F., Landry R.G., Rochette C., et al. Effectiveness of soft laser treatment in periodontal surgery. Int Dent J. 1993;43(2):121–127. - PubMed
    1. Choukroun J., Diss A., Simonpieri A., et al. Platelet-rich fibrin (PRF): a second — generation platelet concentrate. Part V: Histologic Evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):299–303. doi: 10.1016/j.tripleo.2005.07.012. - DOI - PubMed
    1. Kim S.G., Kim W.K., Park J.C., Kim H.J. A comparative study of osseointegration of Avana Implants in a Demineralized Freeze-Dried Bone Alone or With Platelet-Rich Plasma. J Oral Maxillofac Surg. 2002;60(9):1018–1025. doi: 10.1053/joms.2002.34413. - DOI - PubMed

LinkOut - more resources