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Comment
. 2012 Nov 8;16(6):170.
doi: 10.1186/cc11508.

Cell-free DNA and outcome in sepsis

Andrew Rhodes, Maurizio Cecconi
Comment

Cell-free DNA and outcome in sepsis

Andrew Rhodes et al. Crit Care. .

Abstract

Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition and the lack of a biomarker able to accurately confirm the condition, the diagnosis of sepsis is challenging. Even more challenging is the prediction of how these patients will respond to the therapy and whether they will survive the intensive care and the hospital admission.

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References

    1. Kehl DW, Iqbal N, Fard A, Kipper BA, De La Parra Landa A, Maisel AS. Biomarkers in acute myocardial injury. Transl Res. 2012;16:252–264. doi: 10.1016/j.trsl.2011.11.002. - DOI - PubMed
    1. Al-Subaie N, Reynolds T, Myers A, Sunderland R, Rhodes A, Grounds RM, Hall GM. C-reactive protein as a predictor of outcome after discharge from the intensive care: a prospective observational study. Br J Anaesth. 2010;16:318–325. doi: 10.1093/bja/aeq171. - DOI - PubMed
    1. Pierrakos C, Vincent J-L. Sepsis biomarkers: a review. Crit Care. 2010;16:R15. doi: 10.1186/cc8872. - DOI - PMC - PubMed
    1. Butt AN, Swaminathan R. Overview of circulating nucleic acids in plasma/serum. Ann N Y Acad Sci. 2008;16:236–242. doi: 10.1196/annals.1448.002. - DOI - PubMed
    1. Huttunen R, Kuparinen T, Jylhävä J, Aittoniemi J, Vuento R, Huhtala H, Laine J, Syrjänen J, Hurme M. Fatal outcome in bacteremia is characterized by high plasma cell free DNA concentration and apoptotic DNA fragmentation: a prospective cohort study. PLoS ONE. 2011;16:e21700. doi: 10.1371/journal.pone.0021700. - DOI - PMC - PubMed