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. 2013;27(17):1562-8.
doi: 10.1080/14786419.2012.738206. Epub 2012 Nov 9.

New secondary metabolites from bioactive extracts of the fungus Armillaria tabescens

H M T Bandara Herath  1 , Melissa Jacob, A Dan Wilson, Hamed K Abbas, N P Dhammika Nanayakkara
Affiliations

New secondary metabolites from bioactive extracts of the fungus Armillaria tabescens

H M T Bandara Herath et al. Nat Prod Res. 2013.

Abstract

Ethyl acetate extracts of Armillaria tabescens (strain JNB-OZ344) showed significant fungistatic and bacteristatic activities against several major human pathogens including Candida albicans, Cryptococcus neoformans, Escherichia coli and Mycobacterium intracellulare. Chemical analysis of these extracts led to the isolation and identification of four new compounds, emestrin-F (1), emestrin-G (2), 6-O-(4-O-methyl-β-D-glucopyranosyl)-8-hydroxy-2,7-dimethyl-4H-benzopyran-4-one (3) and cephalosporolide-J (4), along with five other previously known compounds, emestrin (5), cephalosporolide-E (6), decarestrictine-C2 (7), ergosterol and brassicasterol. Structural elucidation of all compounds was carried out by NMR and MS analyses. Antimicrobial assays revealed that compounds 1 and 5 were responsible for the observed growth inhibitory activities of the fungal extracts against the human pathogens tested.

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