Planar cell polarity in coordinated and directed movements

Abstract

Planar cell polarity is a fundamental concept to understanding the coordination of cell movements in the plane of a tissue. Since the planar cell polarity pathway was discovered in mesenchymal tissues involving cell interaction during vertebrate gastrulation, there is an emerging evidence that a variety of mesenchymal and epithelial cells utilize this genetic pathway to mediate the coordination of cells in directed movements. In this review, we focus on how the planar cell polarity pathway is mediated by migrating cells to communicate with one another in different developmental processes.