[Research of eye diseases associated with PERK mediated endoplasmic reticulum stress]

Abstract

Endoplasmic reticulum is the organelle where proteins get folded and assembled, and all kinds of damage factors can lead to the accumulation of unfolded proteins, therefore initiate endoplasmic reticulum stress (ERS) by activating the intracellular signal transduction pathways-cumulatively called the unfolded protein response, either to protect cells or to induce cell apoptosis. PERK pathway has been considered as a main signal transduction pathway of ERS, and a lot of eye diseases are correlated with PERK pathway mediated ERS. This article mainly summarize the progress of the eye diseases associated with PERK pathway mediated ERS.