Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Dec;17(12):1258-60.
doi: 10.1007/s10495-012-0777-3.

Retinal endothelial cell apoptosis

Jena J Steinle  1
Affiliations
Review

Retinal endothelial cell apoptosis

Jena J Steinle. Apoptosis. 2012 Dec.

Abstract

Retinal endothelial cell (REC) apoptosis occurs in response to a number of stressors, including high glucose, oxidative stress, hypoxia. Because these stressors are common factors in a number of ocular diseases, it is critical to understand the cellular mechanisms by which apoptosis occurs in REC. This review discusses the various models of REC used in ophthalmological research. The mechanisms responsible for REC apoptosis are discussed, as well as potential therapeutics currently under development to prevent REC apoptosis. The primary goal of this review is provide the reader with a background knowledge of the current state of research ongoing in REC apoptosis and potential avenues for future testing.

PubMed Disclaimer

References

    1. Cai J, Wu L, Qi X, et al. PEDF regulates vascular permeability by a gamma-secretase-mediated pathway. PLoS ONE. 2011;6:e21164. - PMC - PubMed
    1. Williams KP, Steinle JJ. Maintenance of beta-adrenergic receptor signaling can reduce fas signaling in human retinal endothelial cells. Exp Eye Res. 2009;89:448–455. - PubMed
    1. Busik JV, Mohr S, Grant MB. Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. Diabetes. 2008;57:1952–65. - PMC - PubMed
    1. Panjala SR, Steinle JJ. Insulin and beta-adrenergic receptors inhibit retinal endothelial cell apoptosis through independent pathways. Neurochemical research. 2011;36:604–12. - PubMed
    1. Panjala SR, Steinle JJ. Insulin and beta-adrenergic Receptors Inhibit Retinal Endothelial Cell Apoptosis Through Independent Pathways. Neurochem Res. 2010 - PubMed

Publication types