One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions
- PMID: 23143149
- PMCID: PMC6269035
- DOI: 10.3390/molecules171113368
One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions
Abstract
One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions in the presence of Na(2)CO(3), gave the corresponding 2-phenylimidazo[1,2-α]pyridines in excellent yields ranging from 72% to 89%.
Figures
References
-
- Adib M., Sheikhi E., Rezaei N. One-pot synthesis of imidazo[1,2-a]pyridines from benzyl halides or benzyltosylates, 2-aminopyridines and isocyanides. Tetrahed. Lett. 2012;52:3191–3194.
-
- Chiacchio A.D., Rimoli M.G., Avllone L., Arena F., Abignente E., Filippelli W., Filippelli A., Falcone G. 2-Phenylimidazo[1,2-a]pyridine-3-carboxylic acid derivatives: Synthesis and antiinflammatory activity. Arch. Pharm. Pharm. Med. Chem. 1998;331:273–278. doi: 10.1002/(SICI)1521-4184(19989)331:9<273::AID-ARDP273>3.0.CO;2-R. - DOI - PubMed
-
- Ismail M.A., Arafa R.K., Wenzler T., Brun R., Tanious F.A., Wilsona W.D., Boykina D.W. Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines. Bioorg. Med. Chem. 2008;16:683–691. doi: 10.1016/j.bmc.2007.10.042. - DOI - PubMed
-
- Elhakmoui A., Gueiffier A., Milhavet J.C., Blache Y., Chapat J.P. Synthesis and antiviral activity of 3-substituted imidazo[1,2-a]pyridines. Bioorg. Med. Chem. Lett. 1994;4:1937–1940. doi: 10.1016/S0960-894X(01)80538-2. - DOI
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources