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. 2012 Nov;26(6):493-6.
doi: 10.1002/jcla.21552.

Mean platelet volume in neonatal sepsis

Mehmet Yekta Oncel  1 , Ramazan Ozdemir, Sadik Yurttutan, Fuat Emre Canpolat, Omer Erdeve, Serife Suna Oguz, Nurdan Uras, Ugur Dilmen
Affiliations

Mean platelet volume in neonatal sepsis

Mehmet Yekta Oncel et al. J Clin Lab Anal. 2012 Nov.

Abstract

Background: The aim of this study was to investigate any changes in mean platelet volume (MPV) in patients with neonatal sepsis (NS).

Methods: Subjects were stratified into two groups: proven sepsis (Group 1a) and clinical sepsis (Group 1b). The control group (Group 2) consisted of healthy newborns matched for gestational age and birth weight.

Results: A total of 100 patients with NS (35 with proven sepsis and 65 with clinical sepsis) and 50 healthy controls were enrolled. A comparison of markers of sepsis obtained at baseline revealed white blood cell count (WBC), C-reactive protein (CRP), interleukin-6 (IL-6), and MPV levels to be significantly higher in newborns with sepsis compared to healthy controls (P = 0.01, <0.001, <0.001, and 0.001, respectively). Mean baseline serum levels of CRP and MPV were significantly higher in Group 1a compared to Group 1b (P = 0.003, P = 0.007, respectively), whereas the difference between group with regards to baseline serum levels of IL-6 and platelet count was statistically insignificant (P = 0.14, P = 0.28, respectively).

Conclusion: This is the first study to demonstrate a statistically significant difference with regard to baseline MPV values between patients with sepsis (proven or clinical) and healthy controls.

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Figures

Figure 1
Figure 1
Plots mean platelet volume (MPV) level of patients with sepsis (n = 100) and control group (n = 50).
See this image and copyright information in PMC

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