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Review
. 2013 Jan;38(1):252-3.
doi: 10.1038/npp.2012.182.

Translational research in OCD: circuitry and mechanisms

Suzanne N Haber  1 , Sarah R Heilbronner
Affiliations
Review

Translational research in OCD: circuitry and mechanisms

Suzanne N Haber et al. Neuropsychopharmacology. 2013 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Schematic illustrating key cortical areas involved in obsessive-compulsive disorder (OCD) and their pathways through the internal capsule. (a) Red, orange, and yellow fibers originate in ventromedial prefrontal cortex (vmPFC), orbitofrontal cortex (OFC), and dorsal anterior cingulate (dACC), respectively. The approximate cingulotomy site is depicted as a dark gray oval. (b) Medial view of a sagittal section with vmPFC, OFC, and dACC fibers passing through the internal capsule. The striatum is indicated in gray. A model of the electrode with its four contacts is placed at ventral internal capsule (VC)/ventral striatum (VS) deep brain stimulation (DBS) site. (c) Lateral view of a sagittal section shows the four electrode contact points in the VC/VS. VmPFC and OFC fibers pass through the ventral contacts, and OFC and dACC fibers pass through the dorsal contact points (Lehman et al, 2011). Action potential symbols indicate possible regions with changes in firing rates and/or local field potentials following HFS in the VS (McCracken and Grace, 2009); stars indicate regions with possible changes in plasticity following HFS to VS (Rodriguez-Romaguera et al, 2012).
See this image and copyright information in PMC

References

    1. Gillan CM, Papmeyer M, Morein-Zamir S, Sahakian BJ, Fineberg NA, Robbins TW, et al. Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder. Am J Psychiatry. 2011;168:718–726. - PMC - PubMed
    1. Greenberg BD, Rauch SL, Haber SN. Invasive Circuitry-Based Neurotherapeutics: Stereotactic Ablation and Deep Brain Stimulation for OCD. Neuropsychopharmacology. 2010;35:317–336. - PMC - PubMed
    1. Lehman JF, Greenberg BD, McIntyre CC, Rasmussen SA, Haber SN. Rules ventral prefrontal cortical axons use to reach their targets: implications for diffusion tensor imaging tractography and deep brain stimulation for psychiatric illness. J Neurosci. 2011;31:10392–10402. - PMC - PubMed
    1. McCracken CB, Grace AA. Nucleus accumbens deep brain stimulation produces region-specific alterations in local field potential oscillations and evoked responses in vivo. J Neurosci. 2009;29:5354–5363. - PMC - PubMed
    1. Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry. 2007;62:446–454. - PubMed

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