Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Feb 28;211(2):176-9.
doi: 10.1016/j.pscychresns.2012.05.007. Epub 2012 Nov 11.

A window into the invisible wound of war: functional neuroimaging of REM sleep in returning combat veterans with PTSD

Anne Germain  1 , Jeffrey James, Salvatore Insana, Ryan J Herringa, Oommen Mammen, Julie Price, Eric Nofzinger
Affiliations

A window into the invisible wound of war: functional neuroimaging of REM sleep in returning combat veterans with PTSD

Anne Germain et al. Psychiatry Res. .

Abstract

Relative regional cerebral metabolic rate of glucose in rapid eye movement (REM) sleep and wakefulness was explored in combat veterans with and without posttraumatic stress disorder PTSD, using positron emission tomography. Hypermetabolism in brain regions involved in arousal regulation, fear responses, and reward processing persist during REM sleep in combat veterans with PTSD.

PubMed Disclaimer

Conflict of interest statement

Disclosures: Dr. Germain has served as a consultant for Concurrent Technologies Corporation. Dr. Nofzinger reports equity ownership in Cereve Inc. Drs. Mammen, Price, Herringa, Insana, and Mr. James report no conflict of interest.

Figures

Figure 1
Figure 1
Render images (A) and axial planes (B) depicting brain regions where veterans with PTSD show greater relative rCMRglc than control veterans without PTSD (CTL) during wakefulness (WAKE) and rapid-eye movement (REM) sleep. Statistical maxima were identified in MNI (x, y, z) coordinates. The alpha level for significance was set at 0.05, with family-wise error (FWE) correction for multiple comparisons.
Figure 1
Figure 1
Render images (A) and axial planes (B) depicting brain regions where veterans with PTSD show greater relative rCMRglc than control veterans without PTSD (CTL) during wakefulness (WAKE) and rapid-eye movement (REM) sleep. Statistical maxima were identified in MNI (x, y, z) coordinates. The alpha level for significance was set at 0.05, with family-wise error (FWE) correction for multiple comparisons.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM. The development of a Clinician-Administered PTSD Scale. Journal of Traumatic Stress. 1995;8(1):75–90. - PubMed
    1. French L, McCrea M, Baggett M. The Military Acute Concussion Evaluation (MACE) Journal of Special Operations Medicine. 2008;8(1):68–77.
    1. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV) Washington, D.C: American Psychiatric Press, Inc.; 1996.
    1. Forbes EE. Where's the fun in that? Broadening the focus on reward function in depression. Biological Psychiatry 6. 2009;6(3):199–200. - PMC - PubMed
    1. Germain A, Buysse DJ, Nofzinger E. Sleep-specific mechanisms underlying posttraumatic stress disorder: integrative review and neurobiological hypotheses. Sleep Medicine Reviews. 2008;12(3):185–195. - PMC - PubMed

Publication types

MeSH terms