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. 2013 Feb 28;211(2):176-9.
doi: 10.1016/j.pscychresns.2012.05.007. Epub 2012 Nov 11.

A window into the invisible wound of war: functional neuroimaging of REM sleep in returning combat veterans with PTSD

Anne Germain  1 , Jeffrey James, Salvatore Insana, Ryan J Herringa, Oommen Mammen, Julie Price, Eric Nofzinger
Affiliations

A window into the invisible wound of war: functional neuroimaging of REM sleep in returning combat veterans with PTSD

Anne Germain et al. Psychiatry Res. .

Abstract

Relative regional cerebral metabolic rate of glucose in rapid eye movement (REM) sleep and wakefulness was explored in combat veterans with and without posttraumatic stress disorder PTSD, using positron emission tomography. Hypermetabolism in brain regions involved in arousal regulation, fear responses, and reward processing persist during REM sleep in combat veterans with PTSD.

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Conflict of interest statement

Disclosures: Dr. Germain has served as a consultant for Concurrent Technologies Corporation. Dr. Nofzinger reports equity ownership in Cereve Inc. Drs. Mammen, Price, Herringa, Insana, and Mr. James report no conflict of interest.

Figures

Figure 1
Figure 1
Render images (A) and axial planes (B) depicting brain regions where veterans with PTSD show greater relative rCMRglc than control veterans without PTSD (CTL) during wakefulness (WAKE) and rapid-eye movement (REM) sleep. Statistical maxima were identified in MNI (x, y, z) coordinates. The alpha level for significance was set at 0.05, with family-wise error (FWE) correction for multiple comparisons.
Figure 1
Figure 1
Render images (A) and axial planes (B) depicting brain regions where veterans with PTSD show greater relative rCMRglc than control veterans without PTSD (CTL) during wakefulness (WAKE) and rapid-eye movement (REM) sleep. Statistical maxima were identified in MNI (x, y, z) coordinates. The alpha level for significance was set at 0.05, with family-wise error (FWE) correction for multiple comparisons.
See this image and copyright information in PMC

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