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. 2013:935:99-109.
doi: 10.1007/978-1-62703-080-9_7.

N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: a mouse model of acute retinal ganglion cell damage

Roswitha Seitz  1 , Ernst R Tamm
Affiliations

N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: a mouse model of acute retinal ganglion cell damage

Roswitha Seitz et al. Methods Mol Biol. 2013.

Abstract

The animal model of N-methyl-D-aspartate (NMDA)-induced excitotoxic damage of retinal ganglion cells (RGC) is widely used to study the molecular mechanisms of RGC apoptosis and/or its prevention by neuroprotective agents. This chapter provides protocols for applying NMDA-induced excitotoxic damage to RGC of mouse eyes and for subsequent measuring of the extent of the resulting damage.

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