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. 2012 Nov 14:12:22.
doi: 10.1186/1472-6890-12-22.

Trop-2 protein overexpression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma

Eliana Bignotti  1 , Laura Zanotti, Stefano Calza, Marcella Falchetti, Silvia Lonardi, Antonella Ravaggi, Chiara Romani, Paola Todeschini, Elisabetta Bandiera, Renata A Tassi, Fabio Facchetti, Enrico Sartori, Sergio Pecorelli, Dana M Roque, Alessandro D Santin
Affiliations

Trop-2 protein overexpression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma

Eliana Bignotti et al. BMC Clin Pathol. .

Abstract

Background: Endometrial cancer is the most common gynecologic malignancy in developed countries. Trop-2 is a glycoprotein involved in cellular signal transduction and is differentially overexpressed relative to normal tissue in a variety of human adenocarcinomas, including endometrioid endometrial carcinomas (EEC). Trop-2 overexpression has been proposed as a marker for biologically aggressive tumor phenotypes.

Methods: Trop-2 protein expression was quantified using tissue microarrays consisting of formalin-fixed paraffin-embedded specimens from 118 patients who underwent surgical staging from 2001-9 by laparotomy for EEC. Clinicopathologic characteristics including age, stage, grade, lymphovascular space invasion, and medical comorbidities were correlated with immunostaining score. Univariate and multivariate analyses were performed for overall survival, disease-free survival, and progression-free survival in relation to clinical parameters and Trop-2 protein expression.

Results: Clinical outcome data were available for 103 patients. Strong Trop-2 immunostaining was significantly associated with higher tumor grade (p=0.02) and cervical involvement (p<0.01). Univariate analyses showed a significant association with reduced disease-free survival (DFS) (p=0.01), and a trend towards significance for overall and progression-free survival (p=0.06 and p=0.05, respectively). Multivariate analyses revealed Trop-2 overexpression and advanced FIGO stage to be independent prognostic factors for poor DFS (p=0.04 and p <0.001, respectively).

Conclusions: Trop-2 protein overexpression is significantly associated with higher tumor grade and serves as an independent prognostic factor for DFS in endometrioid endometrial cancer.

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Figures

Figure 1
Figure 1
Univariate survival analysis according to Trop-2 immunostaining on 103 EEC patients. Kaplan-Meier survival curves displaying that stronger Trop-2 immunostaining (IHC score 3 versus IHC score 0/1/2) exhibits a significant association with reduced DFS (Figure 1A, p=0.01), while it shows a trend towards significance for overall and progression-free survival (Figure 1B and 1C, p=0.06 and p=0.05, respectively) on a cohort of 103 EEC patients.
See this image and copyright information in PMC

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