NICE clinical guideline (CG152): the management of Crohn's disease in adults, children and young people

Abstract

Background: The guideline offers best practice advice on the care of adults, children and young people with Crohn's disease.

Aim: To provide clinically effective and cost-effective evidence-based recommendations to guide clinical practice in a clinical guideline commissioned by the National Institute for Health and Clinical Excellence (NICE).

Methods: A systematic review of the evidence including critical appraisal, meta-analysis and cost-effectiveness modelling.

Results: Thirty-one evidence-based recommendations covering induction and maintenance therapy are available. Five key priorities for implementation are identified together with nine future research recommendations. Three guideline versions are available: short (containing just the recommendations), full (containing the full evidence base) and an Understanding NICE guidance for patients and carers. Algorithms have been produced together with a NICE pathway and implementation tools.

Conclusion: These are the first evidence-based clinical and cost-effectiveness guidelines for Crohn's disease in the United Kingdom.