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Case Reports
. 2013 Jan;51(1):369-72.
doi: 10.1128/JCM.02234-12. Epub 2012 Nov 14.

Emergence of OXA-48 and OXA-181 carbapenemases among Enterobacteriaceae in South Africa and evidence of in vivo selection of colistin resistance as a consequence of selective decontamination of the gastrointestinal tract

Adrian J Brink  1 , Jennifer Coetzee, Craig Corcoran, Cornelis G Clay, Danusha Hari-Makkan, Rachael K Jacobson, Guy A Richards, Charles Feldman, Louise Nutt, Johan van Greune, J D Deetlefs, Karin Swart, Lesley Devenish, Laurent Poirel, Patrice Nordmann
Affiliations
Case Reports

Emergence of OXA-48 and OXA-181 carbapenemases among Enterobacteriaceae in South Africa and evidence of in vivo selection of colistin resistance as a consequence of selective decontamination of the gastrointestinal tract

Adrian J Brink et al. J Clin Microbiol. 2013 Jan.

Abstract

This study reports on the emergence of OXA-48-like carbapenemases among isolates of Enterobacteriaceae in South Africa. In addition, the emergence during therapy of a colistin-resistant OXA-181-producing Klebsiella pneumoniae isolate was documented following selective digestive tract decontamination with oral colistin, which is therefore strongly discouraged.

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References

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