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. 2013 Jan;103(1):99-104.
doi: 10.2105/AJPH.2012.300743. Epub 2012 Nov 15.

Fundamental causes of colorectal cancer mortality in the United States: understanding the importance of socioeconomic status in creating inequality in mortality

Nallely Saldana-Ruiz  1 , Sean A P Clouston, Marcie S Rubin, Cynthia G Colen, Bruce G Link
Affiliations

Fundamental causes of colorectal cancer mortality in the United States: understanding the importance of socioeconomic status in creating inequality in mortality

Nallely Saldana-Ruiz et al. Am J Public Health. 2013 Jan.

Abstract

Objectives: We used the fundamental cause hypothesis as a framework for understanding the creation of health disparities in colorectal cancer mortality in the United States from 1968 to 2005.

Methods: We used negative binomial regression to analyze trends in county-level gender-, race-, and age-adjusted colorectal cancer mortality rates among individuals aged 35 years or older.

Results: Prior to 1980, there was a stable gradient in colorectal cancer mortality, with people living in counties of higher socioeconomic status (SES) being at greater risk than people living in lower SES counties. Beginning in 1980, this gradient began to narrow and then reversed as people living in higher SES counties experienced greater reductions in colorectal cancer mortality than those in lower SES counties.

Conclusions: Our findings support the fundamental cause hypothesis: once knowledge about prevention and treatment of colorectal cancer became available, social and economic resources became increasingly important in influencing mortality rates.

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Figures

FIGURE 1—
FIGURE 1—
Age-, race-, and gender-adjusted colorectal cancer mortality rates (per 10 000 individuals aged ≥ 35 years) and trends (solid line) before and after publication of the American Cancer Society (ACS) guidelines and US Multi-Society Task Force (MSTF) recommendations: United States, 1968–2005.
FIGURE 2—
FIGURE 2—
Socioeconomic status (SES) gradients in age-, race-, and gender-adjusted colorectal cancer mortality rates and trends for each SES tertile before and after publication of the American Cancer Society (ACS) guidelines and US Multi-Society Task Force (MSTF) recommendations: United States, 1968–2005, and projections to 2015.
See this image and copyright information in PMC

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