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. 1990 Mar;87(6):2220-4.
doi: 10.1073/pnas.87.6.2220.

Recombinant human bone morphogenetic protein induces bone formation

E A Wang  1 , V Rosen, J S D'Alessandro, M Bauduy, P Cordes, T Harada, D I Israel, R M Hewick, K M Kerns, P LaPan, et al.
Affiliations

Recombinant human bone morphogenetic protein induces bone formation

E A Wang et al. Proc Natl Acad Sci U S A. 1990 Mar.

Abstract

We have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 micrograms of partially purified recombinant human BMP-2A resulted in cartilage by day 7 and bone formation by day 14. The time at which bone formation occurred was dependent on the amount of BMP-2A implanted; at high doses bone formation could be observed at 5 days. The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts. Thus, recombinant BMP-2A has therapeutic potential to promote de novo bone formation in humans.

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