Silencing by throwing away: a role for chromatin diminution
- PMID: 23153488
- DOI: 10.1016/j.devcel.2012.10.022
Silencing by throwing away: a role for chromatin diminution
Erratum in
- Dev Cell. 2012 Dec 11;23(6):1263
Abstract
Chromatin diminution during development generates cells with varying genetic content within the same organism. Two recent papers demonstrate that in two different systems chromatin diminution removes a considerable number of genes from somatic cells, thereby restricting their expression to the germline.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Genetic consequences of programmed genome rearrangement.Curr Biol. 2012 Aug 21;22(16):1524-9. doi: 10.1016/j.cub.2012.06.028. Epub 2012 Jul 19. Curr Biol. 2012. PMID: 22818913 Free PMC article.
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Silencing of germline-expressed genes by DNA elimination in somatic cells.Dev Cell. 2012 Nov 13;23(5):1072-80. doi: 10.1016/j.devcel.2012.09.020. Epub 2012 Nov 1. Dev Cell. 2012. PMID: 23123092 Free PMC article.
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