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Comment
. 2012 Nov 13;23(5):921-3.
doi: 10.1016/j.devcel.2012.10.025.

IRE1, a double-edged sword in pre-miRNA slicing and cell death

Justin Hassler  1 , Stewart S Cao, Randal J Kaufman
Affiliations
Comment

IRE1, a double-edged sword in pre-miRNA slicing and cell death

Justin Hassler et al. Dev Cell. .

Abstract

IRE1α, the most conserved transducer of the unfolded protein response, plays critical roles in many biological processes and cell fate decisions. Reporting in Science, Upton et al. (2012) broadened our understanding of IRE1α as a cell-death executioner, showing that upon ER stress, IRE1α degrades microRNAs to promote translation of caspase-2.

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Figures

Figure 1
Figure 1. IRE1α-mediated signaling of life and death
Dimerization of IRE1α induces its activation and initiates downstream signaling through the recruitment of TRAF2 and RNase activation to promote Xbp1 mRNA splicing, degradation of mRNAs, and degradation of miRNAs.
See this image and copyright information in PMC

Comment on

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